Common genetic variants in sudden cardiac death

Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study.

BACKGROUND Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded relationship to SCD, and 35% to 45% of its variation is heritable. We examined the relationship among recently reported common genetic variants, QT interval, and SCD. METHODS AND RESULTS We genotyped 15 common (minor allele frequency >1%) ca...

Cumulative effects of common genetic variants on risk of sudden cardiac death

BACKGROUND Genome-wide association studies and candidate-gene based approaches have identified multiple common variants associated with increased risk of sudden cardiac death (SCD). However, the independent contribution of these individual loci to disease risk is modest. OBJECTIVE To investigate the cumulative effects of genetic variants previously associated with SCD risk. METHODS A total ...

Predicting sudden cardiac death using common genetic risk variants for coronary artery disease.

AIMS Genome-wide association studies (GWAS) have identified many variants associating with an increased risk of coronary artery disease (CAD). We studied the possible association between these variants and the risk of sudden cardiac death (SCD). METHODS AND RESULTS A weighted genetic risk score (GRSCAD) was formed from variants most strongly associating with CAD identified by the CARDIoGRAMpl...

Common Genetic Variants Associated with Sudden Cardiac Death: The FinSCDgen Study

BACKGROUND Sudden cardiac death (SCD) accounts for up to half of cardiac mortality. The risk of SCD is heritable but the underlying genetic variants are largely unknown. We investigated whether common genetic variants predisposing to arrhythmia or related electrocardiographic phenotypes, including QT-interval prolongation, are associated with increased risk of SCD. METHODOLOGY/PRINCIPAL FINDI...

Common Variants in Cardiac Ion Channel Genes are Associated with Sudden Cardiac Death Running Title: Albert et al; Common Ion Channel Variants and Sudden Death